Phytomedicinal and Ameliorative Effect of Ethanol Leaf Extract of Corchorus olitorius on Carbon Tetrachloride Induced Hepatic Toxicity | Chapter 01 | Recent Advances in Biological Research Vol. 5
Liver, the engine house for biotransformation of xenobiotics serves as a receiving depot, processing factory and redistribution center of the body. In the light of these roles, the effect of ethanol leaf extract of Corchorus olitorius on CCl4 induced liver damage in wistar rats was assessed. CCl4 (0.5 ml/kg) was used to induced hepatotoxicity. 25-albino rats of wistar strain (120–150 g) were used for the study and were divided into five groups of five rats per group. Group A serves as normal control and was given distilled water of treatment equivalence, group B serves as a negative control and was treated with CCl4 and olive oil as a vehicle at the ratio of 1:1. Group C, D, and E were induced with CCl4 and the extract administered through oral gavages at scalar doses of 500 mg/kg, 750 mg/kg and 1 g/kg daily. The administration lasted for 15 days period after which the animals were sacrificed. Serum enzyme assay revealed that there was a marked reduction in the elevated activity of the hepatic enzymes viz alanine aminotransferase (ALT) A (71.2±3.27), B (98.8±2.61), C (78.0±3.74), D (74.8±2.77), and 74.6±1.95) respectively. Similar trend was observed for aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels when compared with the controls (P=.05). More so, the result revealed that the extract lowers serum albumin, no significant change in billirubin but increased total protein levels in all treated groups when compared with the controls (P=.05). Furthermore, it showed a significant decrease (P=.05) in White blood cell count (WBC), and platelet but no significant decrease (P=.05) in packed cell volume (PCV) and Hb. From the above findings, it is obvious that the ethanol leaf extract of Corchorus olitorius could have hepatoprotective property.
Author(s) Details
O. F. Ujah
Department of Chemical Sciences, College of Natural Sciences, University of Mkar, Mkar, P.M.B. 017, Benue State, Nigeria.
P. H. Nenge
Department of Chemical Sciences, College of Natural Sciences, University of Mkar, Mkar, P.M.B. 017, Benue State, Nigeria.
B. O. Abdulrahman
Department of Biochemistry and Molecular Biology, Faculty of Life Sciences, Federal University Dutsinma, P.M.B 5001, Katsina State, Nigeria.
Mrs. I. R. Ujah
Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, P.M.B. 5323, Port Harcourt, River State, Nigeria.
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