CONCLUSIONS: We detected distinct genetic loci underpinning the diameters of the LVOT, aortic root, and at several segments of ascending aorta. We spatially defined a region of aorta whose genetics may be most relevant to predicting thoracic aortic aneurysm. We further described a genetic signature that may predispose to aortic stenosis. Understanding genetic contributions to proximal aortic diameter may enable identification of individuals at risk for aortic disease and facilitate… https://pubmed.ncbi.nlm.nih.gov/35902171/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1HaIafHQm-6ixXDuOGQDZK3BTBlRSE5zc5tHU8zzzboDtqXsyi&fc=20220702142008&ff=20220729010139&v=2.17.7

--

--

The Pediatric Heart Network (PHN) trial showed similar efficacy of β-blockers (BB) and angiotensin receptor blockers (ARB) for aortic root dilation in Marfan syndrome, but the impact on prescription practices is unknown. We hypothesized BB and ARB prescriptions would increase after the trial results were published (2014). Prescription data (2007–2016) were obtained from outpatient encounters (IBM Marketscan) for Marfan syndrome patients (6 months-25 years old). Excluding 2014 as a washout… https://pubmed.ncbi.nlm.nih.gov/35902413/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1HaIafHQm-6ixXDuOGQDZK3BTBlRSE5zc5tHU8zzzboDtqXsyi&fc=20220702142008&ff=20220729010139&v=2.17.7

--

--

BACKGROUND Acute aortic syndrome (AAS) is a spectrum of severe life-threatening disease processes that are often initially encountered in the emergency department (ED) setting and require prompt recognition and treatment to prevent significant complications, including death. We describe an atypical presentation of aortic intramural hematoma in a female patient during sexual intercourse, a situation not previously described in the literature. CASE REPORT The patient was a 45-year-old woman who… https://pubmed.ncbi.nlm.nih.gov/35898118/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1HaIafHQm-6ixXDuOGQDZK3BTBlRSE5zc5tHU8zzzboDtqXsyi&fc=20220702142008&ff=20220728071618&v=2.17.7

--

--