Infectious diseases are a community problem, not an individual problem, and we all need to work together to bring them under control. Right now, that means working together to stop the spread of the new coronavirus which is causing COVID. Symptoms are similar to the flu but can progress to a much worse pneumonia, so it’s important to take it seriously.

The following images are based on CDC recommendations, and make up a new info sheet that is being disseminated to all patients at the Boston Medical Center via their EPIC discharge sheets.

Please share widely. Together we can #FlattenTheCurve!

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The full info sheet in English

Recommendation 1: AVOID CROWDS

Do stay indoors, enjoy quiet outdoor spaces, stay 6 feet (2m) apart, walk your dog. …

You’ve probably read or seen stories about a new virus in Wuhan, China. Scientists are callling it the “novel-Coronavirus” or nCOV, and as of Jan 27 it had been detected in more than 10 countries, with several thousand people infected, hundreds in serious condition, and dozens dead.

That sounds really scary, but right now we don’t know enough about the virus to say for sure what will happen over the next weeks and months. …

A randomized trial explainer

Have you heard that adherence adjustment in randomized clinical trials never works? That’s not true! But many adherence-adjusted analyses fail because the researchers use the wrong methods.

Read on to see the evidence for and against estimating adherence adjusted effects in randomized trial, and learn how modern causal inference tools make adherence adjustment feasible.

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Adherence adjustment lets us ask “What would have happened in our trial if everyone had been assigned to each treatment *and* everyone had received the treatments according to the protocol?”

We begin with a short trip back in time to 1980: the Coronary Drug Project (CDP), a large 6-arm placebo-controlled randomized trial of lipid-lowering medications published a comparison of adherers & non-adherers in their placebo arm. You can read the original CDP paper here: 3

Over 5 years, survival was nearly 10 percentage points higher among people who adhered to placebo most of the time compared to those who didn’t, even after adjusting for ~40 baseline covariates. …


Ellie Murray

Assistant Professor of Epidemiology at Boston University School of Public Health. Follow for causal inference, epidemiology, & data science. Twitter: @epiellie

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