A Comprehensive Guide to Design of Experiments: Concepts, Techniques, and Case Study Analysis

Nilimesh Halder, PhD
5 min readSep 24, 2023

Introduction: The Importance of Design of Experiments in Data Science

Design of Experiments (DOE) is a powerful statistical methodology that enables researchers and practitioners to systematically plan, design, and analyze experiments in a controlled manner. By carefully structuring and analyzing experimental data, DOE allows for the identification of significant factors, interactions, and optimal settings that influence a response variable. In this extensive article, we will discuss the fundamental concepts of DOE, delve into various DOE techniques, and analyze a case study to illustrate the application of these concepts in practice.

1. Fundamental Concepts of Design of Experiments

1.1 Factors and Levels

In the context of DOE, factors are the variables or conditions that can be controlled or manipulated during an experiment. Levels represent the different values or settings of these factors. For example, when testing the effectiveness of a drug, the factors could be dosage and administration frequency, with each factor having multiple levels.

1.2 Response Variables

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