Working with only few fixed grid configurations makes it easy to miss problems while you’re working. Either the developer will find them during implementation — necessitating a lot of annoying back-and-forth — or the broken layouts will end up in your final product.
“Questions are places in your mind where answers fit. If you haven’t asked the question, the answer has nowhere to go. It hits your mind and bounces right off. You have to ask the question — you have to want to know — in order to open up the space for the answer to fit.”