Staying Young With Old Data

infinome
infinome
Jun 23, 2018 · 24 min read
Some preliminary network analysis of the genes over (orange) and under (blue) expressed in aging.

Overexpressed with age

APOD : Apolioprotein D

FCGR2B : Low affinity immunoglobulin gamma Fc receptor II-b

C3 : Complement component 3

CLU : Clusterin

CTSS : Cathepsin S — lysosomal cysteine protease

LYZ : lysozyme

IGJ : J-chain of immunoglobulin

Complement Component 1q : multiple genes (C1QA, C1QB, C1QC)

S100A6

MT1F : Metalothionen

LGALS3 : Galectin-3

MGST1 : Microsomal glutathione s-transferase 1

ANXA3 : Annexin A3

ANXA5 : Annexin A5

S100A4 : calcium binding protein

GPNMB : Osteoactivin

GSTA1 : Glutathione S-transferase 1

VWF : Von Willebrand factor

DERL1 : Derlin-1

NDRG1

ANIA4 : Renamed Dclk1 : doublecortin-like kinase 1

FCGR2A

GBP2

GNS : N-acetylglucosamine-6-sulfatase (NAG!)

IL33 : Interluken 33

MPEG1 : Macrophage-expressed gene 1 protein

NPC2 : NPC intracellular cholesterol transporter 2

ADIPOR2 : Adiponectin receptor 2

B2M

LITAF : lipopolysaccharide-induced TNF-α factor

SERPING1 — Complement C1 inhibitor

HCST

RNF213

C4A : Complement component 4A

SPP1 : Also known as osteopontin

CLIC4

EFEMP1 : EGF-containing fibulin-like extracellular matrix protein 1 (aka Fibulin 3 “FBLN3_HUMAN”)

LAPTM5 : lysosomal-associated protein transmembrane 5

VAT1

HIST1H1C

KIAA0494

PTGES3 — Prostaglandin E synthase 3

LOC360231

RASA3

PSMD11

SGK1 : Serine/Threonine protein kinase, regulated by glucocorticoids, and activated by insulin axis and MTORC2

TXNIP : Thioredoxin binding protein

HLA-G

PCSK6 : Proprotein convertase subtilisin/kexin type 6

Genes underexpressed with age, ranked:

TFRC : Transferrin receptor, important for iron uptake

COLLAGEN (3 genes) :

FABP3 : Heart type fatty acid binding protein

ATP5G3 : subunit of ATP-synthase — this subunit encodes part of the proton channel

NDUFB11 : NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11

CX3CL1 : Fractalkine precursor

CA4 : Carbonic anhydrase 4 — The wikipedia article is fascinating … suggests that lack of carbon dioxide transport out of the lungs may be affected by age

CALB1 : calbindin 1

GHITM : Growth hormone-inducible transmembrane protein

C5ORF13: Renamed NREP :

ACCS2: Cytoplasmic acetyl-coa synthetase

UQCRFS1 : Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

DIABLO : SMAC (second mitochondria-derived activator of caspases)

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infinome is a citizen science experiment to help people lose weight, feel better, and live longer.

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