Toxicological impact of a mimetic estrogen specie: mancozeb on a tadpoles of the green frog (Rana saharica)


The presence in the environment of chemicals with hormone-mimetic properties generates concerns about their effects on aquatic organisms. Due to their estrogenic activity, they are part of the chemical compounds whose concentration level in the environment isn’t monitored. The estrogenic substances can be of natural origin, but also of synthetic origin such as certain pesticides. In order to prevent the risks associated with better use and exposure to xeno-estrogens, we have investigated the effects of estrogen mimetic (MOS) fungal origin (Mancozeb) on the morphology of bio-indicators organisms of pollution: the tadpoles of the green frog (Rana saharica.) Treated with different concentrations 0.25, 0.5, 0.75 and 1 mg/l over a period of 5 weeks. This xenoestrogen induced disturbances of growth and a condition index tadpoles showing a net delay of the breeding and a affection of sexual maturity. We also observe that the exposure of tadpoles populations to different concentrations of the fungicide disrupts their respiratory metabolism in dose-dependent manner. The inhibition of respiration resulted an increase in free radical production, which is confirmed by the test of quantization of reactives metabolites of oxygen (d-ROMs) which highlights a significant production of reactive oxygen species (ROS). Get more like this at:


Source Link

Originally published at: Volume 6, Number 3, March 2015 — JBES