It depends whether you view short-term renting more akin to setting up a lemonade stand outside, or running a daycare out of your home. These types of local regulations are not uncommon for businesses, but are absolutely alien to the average homeowner that is not running a business.
The problem here is that short-term rentals through AirBnb are in a new grey area between things that don’t seem like they should be heavily regulated (little children running lemonade stands) and those that should (daycare in your home). AirBnb makes it really, really easy for you to operate a business that competes directly with a much more regulated industry (hotels).
So if you’re a true believer in the sharing economy and that the ease of entry should be an indication that it’s more like something that shouldn’t be regulated, then Prop F is absolutely worse than similar regulations (again, lemonade stands). If you think the sharing economy is a subterfuge for evading regulation and that the specific market should determine regulation (not ease of entry), then Prop F has many parallels in the business world.