I have a few friends who have done exactly this in small towns in WV and Ohio: breweries, letterpresses, bars, bike shops, natural food stores, etc. Property is cheap in a lot of these towns, and if you’re able to have an online component, all the better. The businesses that are less dependent on foot traffic (breweries with some local distribution, etc.) seem to do better for obvious reasons. Mr. McDillet and I have discussed doing something similar some day, but would probably have something ag-based without a storefront of our own.