Evaluation of Pharmacologically Interesting Dose Range of Ascorbic Acid in Mice

Objective: Ascorbic acid is the most abundant water-soluble naturally occurring organic compound with antioxidant properties. It serves as a cofactor for enzymes involved in hormone biosynthesis, and the regeneration of antioxidants. Plants and food rich in ascorbic acid have been widely used in Ayurveda to treat a variety of psychologically stress related disorders. Materials and Methods: The experimental protocol was designed to evaluate the oral efficacies of ascorbic acid for putative adaptogenic activity in male mice. A battery of behaviour test models viz. stress-induced hyperthermia, tail suspension test, and pentobarbital-induced hypnosis were used to evaluate the adaptogenic activity of ascorbic acid. Mice were divided in different groups, and were orally administered with daily doses of ascorbic acid (5, 25, 125 and 625 mg/kg) solution (10 ml/kg) prepared with pH balanced distilled water for 11 consecutive days. For assessing long term effects of treatments against stress triggered physiological response, changes in body weights and basal rectal temperatures were also quantified.

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