Metformin like Stress Response Modulating Effects of Turmeric Curcuminoids in Mice

The aim of the study was to compare the protective efficacies of a single and repeated daily oral doses (5, 20, 80, and 320 mg/kg) of a Curcuma longa extract (C. longa) enriched in curcuminoids (95.4%) with those of metformin (100 mg/kg) against intermittent foot shock stress triggered body weight changes and thermoregulatory responses in male and female mice. No significant effects of both the test agents on basal rectal temperature, or on short duration of foot shock stress triggered transient hyperthermia were observed one hour after their single oral doses.

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