What is Latent Tuberculosis?

Carson Martin
6 min readSep 23, 2024

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Latent tuberculosis (TB) is a condition in which an individual is infected with Mycobacterium tuberculosis, the bacteria that cause TB, but does not show any symptoms of the disease. Unlike active TB, where the bacteria multiply and cause illness, latent TB is dormant. Individuals with latent TB do not feel sick, are not contagious, and typically do not even know they are infected unless they undergo testing. However, latent TB has the potential to progress into active TB, particularly if the immune system weakens.

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Understanding Latent TB

Tuberculosis is transmitted through airborne particles when a person with active TB coughs, sneezes, or talks. Once the bacteria enter the body, the immune system often controls the infection and prevents it from spreading. This leads to the latent form of the disease. During this stage, the bacteria remain in an inactive state, often for years, without causing harm.

It is estimated that up to a quarter of the worldโ€™s population has latent TB, but only a small percentage of these individuals will go on to develop active TB. However, latent TB can become active if the immune system becomes compromised due to factors such as HIV/AIDS, diabetes, or malnutrition. Smoking and the use of immunosuppressive medications can also trigger the progression to active TB.

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How is Latent TB Diagnosed?

Latent TB can only be detected through specific testing, as it does not present any symptoms. There are two primary tests used to diagnose latent TB:

Tuberculin Skin Test (TST): A small amount of tuberculin is injected into the skin of the arm. If the individual has latent TB, the injection site will show a reaction after 48โ€“72 hours.

Interferon Gamma Release Assay (IGRA): This blood test measures the bodyโ€™s immune response to TB bacteria and is considered more accurate than the TST, especially in individuals who have received the Bacillus Calmette-Guรฉrin (BCG) vaccine.

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Treatment for Latent TB

While latent TB is not contagious, it can develop into active TB if left untreated, posing a significant public health risk. To prevent this, individuals with latent TB are often prescribed antibiotics to reduce the risk of progression. The most common treatment is a 3โ€“9 month course of isoniazid, rifapentine, or rifampin, which kills the dormant bacteria before they become active. Taking these medications as prescribed is crucial to preventing the development of active TB.

Who is at Risk of Progression to Active TB?

Certain groups of people are more likely to progress from latent TB to active TB. These include:

  • Individuals with weakened immune systems (e.g., those with HIV, diabetes, or undergoing chemotherapy)
  • Recent contacts of people with active TB
  • People who have not received adequate TB treatment in the past
  • Smokers and those with substance abuse issues

By identifying and treating those with latent TB, the spread of TB can be better controlled and prevented.

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Conclusion

Latent tuberculosis is a silent form of TB where the bacteria remain dormant in the body without causing symptoms. Although it is not contagious, there is a risk of latent TB progressing to active TB, especially in individuals with compromised immune systems. Diagnosing and treating latent TB is essential to preventing the spread of active tuberculosis and controlling the disease at a global level.

FAQs

What is latent TB?
Latent TB occurs when an individual is infected with the TB bacteria but does not exhibit symptoms and is not contagious.

Can latent TB become active?
Yes, latent TB can become active, especially if the immune system is weakened by factors like HIV, diabetes, or malnutrition.

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How is latent TB diagnosed?
Latent TB is diagnosed through a tuberculin skin test (TST) or an interferon gamma release assay (IGRA) blood test.

Is treatment necessary for latent TB?
Yes, treatment is recommended to prevent latent TB from progressing to active TB, which can be contagious and more difficult to treat.

Who is at risk for developing active TB from latent TB?
Individuals with weakened immune systems, smokers, and those in close contact with active TB cases are at higher risk of progression.

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Carson Martin
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Exploring strategies for managing stress ๐Ÿ˜Œ, health challenges โš•๏ธ, and maintaining financial control.