Image for post
Image for post

A CRISPR-mediated Coronavirus Treatment and Prevention Strategy

In mid-February, this year, Timothy Abbott, PhD Candidate at Stanford University’s Bioengineering Department, and Dr Marie La Russa, a research scientist working at Dr Stanley Qi’s lab at Stanford, found a way to create a therapeutic agent to prevent all forms of coronavirus.

In this breakthrough research, Abbott was using an approach called PAC-MAN (Prophylactic Antiviral CRISPR in huMAN cells) to attack RNA viruses, which includes the coronavirus family, and degrade their genetic code. …


Transposable Elements and Lifespan Reduction

Survival of the fittest.

The backbone of the Darwinian theory of evolution that we are all familiar with. If a trait makes a certain animal more likely to survive (among other often smaller factors), then that animal will have a higher reproduction rate, leading to more animals in the next generation possessing the advantageous trait. As this cycle continues, the trait eventually becomes common across all members of the species.

Image for post
Image for post
Charles Darwin, father of evolutionary theory and responsible for developing the highly regarded Theory of Evolution | Biography

However, for a species to truly evolve, it must continuously be developing newer traits, which, if helpful for the organism, will be preserved. And these new traits arise from random mutations in one’s genome. These mutations can be caused by a range of factors, like DNA damage caused by the environment (ex. UV radiation), or mistakes made during DNA replication that go unnoticed. These mutations, if they occur in the coding region of the DNA, can cause changes in the structure, or building blocks, of various proteins. These changes often have no effect, but they can also be damaging or advantageous to the organism. If they’re damaging, the species is less likely to reproduce, and the mutation is unlikely to be passed on and preserved. …


Using Yamanaka Factors to Reverse Epigenetic Noise and Regenerate Aged Tissues

In 2006, Dr. Shinya Yamanaka, a Japanese stem cell researcher, published his paper on induced pluripotent stem cells, and it changed the medical world. Dr. Yamanaka had found a way to convert a mature skin cell into a stem cell by injecting just a few genes. And for this, Dr. Yamanaka received the Nobel Prize in Physiology or Medicine in 2012, sharing it with another Sir John B. Gurdon, who found another method of inducing pluripotency.

Image for post
Image for post
Dr. Yamanaka giving a lecture at the Nobel Prize Inspiration Initiative

Thirteen years after this paper was published (in 2019), Dr. Yuancheng Lu from the Sinclair Lab at Harvard University authored another paper (still being peer-reviewed) where he had used Dr. …

About

Akshaj Darbar

17 y/o innovator working on reversing ageing and researching cancer. www.akshajdarbar.com

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store