PinnedAllen CheSeglentis: Crafting a Novel Wine by Blending Two Matured Varietals in a Fresh BottleDiscovering new drug-drug cocrystals (DDCs) has been an exciting and challenging endeavor, especially after the groundbreaking approval of…Jul 24, 2023Jul 24, 2023
PinnedAllen CheEntresto: The first FDA-approved Drug-Drug Co-crystal (DDC) in the New CenturyEntresto stands as the first drug-drug cocrystal (DDC) to have attained commercialization in the past twenty years. It comprises a 1:1…Jun 30, 2023Jun 30, 2023
PinnedAllen CheFDA-Approved Deuterated Drugs and Their SynthesesDeutetrabenazine, marketed by Teva under the brand name AUSTEDO, was granted FDA approval in April 2017 as the first deuterium-substituted…Mar 8, 2023Mar 8, 2023
PinnedAllen CheInstalling the Acrylamide Warheads in the FDA-Approved Covalent DrugsAcrylamides are the earliest-used and the most popular warheads in covalent drug design. The majority of the FDA-approved covalent kinase…Mar 4, 2023Mar 4, 2023
PinnedAllen CheKilo-Scale Synthesis of ARS-2102, a KRAS G12C inhibitorWellspring Biosciences recently published the kilo-scale synthesis of ARS-2102, a second generation of KRAS G12C inhibitor, in OPRD…Mar 2, 2023Mar 2, 2023
Allen CheEU’s Stringent Standards to RSM Designation— A Peek into Two Recent CasesThe EMA review of starting materials for market authorization application of new drugs is “notoriously” stricter than the FDA’s, often…Jan 7Jan 7
Allen CheMutagenic Impurity Control — Option 4Andrew Teasdale (2010, AZ) ApproachDec 24, 2023Dec 24, 2023
Allen CheRSM Designation Risk AnalysisTo download the pdf version of the form: https://shorturl.at/CRVW9Dec 23, 2023Dec 23, 2023
Allen CheIr-catalyzed borylation through C-H Activation, kilo-scale examples in drug synthesisThe Ir-catalyzed borylation through C-H activation of arenes and heteroarenes has been gaining popularity in both academic research and…Jun 13, 2023Jun 13, 2023