What’s worse, the damage isn’t even limited to the browser.
It doesn’t stop at Trello, Facebook, Gmail, Dropbox and AirBnB!
Sacha Greif

What do you mean by damage, Lets not forget, Angular,react,jquery,nodeJs all is library or framework and JavaScript is scripting language these things developed for, so I do not see whats wrong here.

Accessibilty is different topic altogether, if one wants to support browser with disabled js, build a non js version of application.