Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix…

MIF encodes a lymphokine, Macrophage migration inhibitory factor, involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. …

MMP2 is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. 72 kDa type IV collagenase encoded by MMP2 is a gelatinase A, type IV collagenase, that contains three fibronectin type II…

Topics overview: Error-correction code (ECC) sequencing can improve sequencing accuracy, Higher affinity T cell receptors, Molecular afterglow imaging, Human fecal sample processing in metagenomic studies, Pearl millet genome sequence improves agronomic traits in arid environments. 1、Highly accurate fluorogenic DNA sequencing with information theory–based error correction. Eliminating errors in next-generation DNA…

Topics overview: Error-correction code (ECC) sequencing can improve sequencing accuracy, Higher affinity T cell receptors, Molecular afterglow imaging, Human fecal sample processing in metagenomic studies, Pearl millet genome sequence improves agronomic traits in arid environments. 1、Highly accurate fluorogenic DNA sequencing with information theory–based error correction. Eliminating errors in next-generation DNA…

Recently, a new article firstly published in the Journal of Clinical Investigation, identified a growth and differentiation factor 15 (GDF-15), which is secreted by pancreatic cancer cells and protect cancer cells against macrophage-mediated killing. In vitro, tumor-derived GDF-15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and…

Recently, a new article firstly published in the Journal of Clinical Investigation, identified a growth and differentiation factor 15 (GDF-15), which is secreted by pancreatic cancer cells and protect cancer cells against macrophage-mediated killing. In vitro, tumor-derived GDF-15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and…

The mechanistic target of rapamycin encoded by MTOR belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. …

N-cadherin, also known as Cadherin-2 (CDH2) or neural cadherin (NCAD) is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). N-cadherin is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac…