7 Reasons Why MK-677 Ibutamoren is NOT a SARM

Andy
8 min readJul 24, 2023

As a dedicated biohacker, I’ve spent years on a quest to uncover the most effective performance enhancement compounds. In the world of bodybuilding and athletics, one compound that has been gaining significant attention is MK-677 Ibutamoren. It’s being hailed as a game-changer in the realm of Performance Enhancing Drugs (PEDs) because of its ability to enhance growth hormone levels. However, there are misconceptions surrounding it, particularly its classification as a SARM. In this article, “7 Reasons Why MK-677 Ibutamoren is NOT a SARM,” I aim to dispel these myths and shed light on the true nature of this intriguing compound.

Introduction

Today, we’re diving into a hot topic that’s been causing quite a stir — MK-677 Ibutamoren. Is it a SARM or not? Spoiler alert: it’s not.

But why do so many people think it is? And why it’s often classified as one among several Peptides/SARMS/Research chemicals selling websites. Let’s unravel this mystery together!

MK-677, also known as Ibutamoren, is often lumped together with Selective Androgen Receptor Modulators (SARMs). This confusion is understandable, given the similar benefits they offer, such as increased muscle mass and fat loss. However, the similarities end there. The truth is, MK-677 Ibutamoren and SARMs are as different as apples and oranges. Intrigued? Let’s delve deeper.

If you are interested in MK-677, check out my post on Best Mk-677 Brands.

What is MK-677 Ibutamoren?

MK-677, or Ibutamoren, is a potent, long-acting, orally active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.

It’s been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.

Ibutamoren has been associated with vast health benefits. It’s been studied for its potential to increase bone density by altering the metabolism of bone. This makes it a potential therapy for the treatment of osteoporosis. It’s also been shown to alter the metabolism of body fat and so may have application in the treatment of obesity (source).

For fitness enthusiasts, MK-677 is a game-changer. It promotes the growth of lean body mass and boosts muscular strength. It also improves the quality of sleep, skin, and hair. Plus, it’s orally active, which means no more painful injections. Sounds like a dream, right?

What are SARMs?

Now, let’s talk about SARMs. Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds that have similar properties to anabolic agents, but with reduced androgenic properties.

This property allows SARMs the advantage of androgen-receptor specificity, tissue selectivity, and the lack of steroid-related side effects.

SARMs work by selectively binding to androgen receptors in the body. Depending on their chemical structure, they can either block or stimulate these receptors, which can help to promote muscle growth, fat loss, and performance enhancement. Some popular SARMs include Ligandrol (LGD-4033), Ostarine (MK-2866), and Testolone (RAD-140).

Like MK-677, SARMs have been praised for their muscle-building properties. However, they also come with their share of potential side effects, including testosterone suppression and liver damage. It’s also worth noting that SARMs are currently not approved by the FDA for medical use and are legally sold only for “research purposes” (source).

So, while MK-677 and SARMs may seem similar on the surface, they are fundamentally different in their mechanisms of action and their effects on the body. In the following sections, we’ll dive into these differences in more detail.

Common Misconceptions about MK-677 Ibutamoren and SARMs

The fitness world is no stranger to misconceptions, and the confusion between MK-677 Ibutamoren and SARMs is a prime example. The main reason for this mix-up? Both are often marketed towards the same audience — those seeking to enhance their physique and performance.

Many websites and forums categorize MK-677 as a SARM due to its similar benefits, such as increased muscle mass and fat loss. However, this is a classic case of mistaken identity. If you Google it, there are conflicting opinions & articles whether it’s a SARM or not!

Just because two things look similar doesn’t mean they are the same. A dolphin might resemble a fish, but it’s actually a mammal. Similarly, MK-677 might offer some benefits similar to SARMs, but it’s not a SARM.

Let’s go deep in the topic and list 7 reasons why MK-677 Ibutamoren is NOT a SARM!

Reason 1: Differences in Chemical Structure

Let’s get a bit scientific here. The chemical structure of a compound determines its properties and how it interacts with the body. MK-677 Ibutamoren is a non-peptide agonist of the ghrelin receptor. In simpler terms, it’s not a steroid but a growth hormone secretagogue, which means it stimulates the release of growth hormone.

If you’ve come across those “HGH supplements” — those commercially available natural compounds composed of amino acids (like Arginine, L-lysine etc.), L-dopa, Choline, Alpha-GPC, deer antler velvet etc., the way these products are promoted is their ability to stimulate natural growth hormone production from the pituitary gland, via various mechanisms. Here is more information on these kinds of natural supplements & secretagogues.

MK-677 Ibutamoren is kind of an “aggressive HGH supplement”, in the sense that it does the same, albeit much more effectively, (probably because it’s NOT a natural substance but designed to do so). In fact, among the various HGH secreting(stimulating) ingredients possible in a supplement, MK-677 happens to be the most effective, BUT a synthetic substance! Seromax and Myo-HGH are some commercially available MK-677 brands.

On the other hand, SARMs are a type of androgen receptor ligands. They bind to androgen receptors, influencing the DNA of the muscle cells to stimulate muscle growth.

So, despite the similar benefits, the chemical structures of MK-677 and SARMs are as different as chalk and cheese (source).

Reason 2: Different Mechanisms of Action

The mechanism of action is another area where MK-677 and SARMs differ significantly. MK-677 works by mimicking the hormone ghrelin, binding to ghrelin receptors in the brain. This binding stimulates the release of growth hormone and IGF-1, without affecting other hormones like cortisol.

SARMs, however, work by selectively binding to androgen receptors in different tissues. In muscle and bone tissues, they act as effective agonists (activators), promoting growth. But in other tissues like the prostate, they act as antagonists (blockers), preventing unwanted side effects (source).

If you are interested in MK-677, check out my post on Best Mk-677 Brands.

Reason 3: Varied Side Effects

While both MK-677 and SARMs have their benefits, they also come with potential side effects. MK-677 can cause increased appetite, mild lower extremity edema, and muscle pain. However, it doesn’t affect the body’s natural testosterone levels, a significant advantage over SARMs.

SARMs, on the other hand, can lead to testosterone suppression with prolonged use. This can result in side effects like fatigue, mood changes, and loss of libido. They may also cause liver damage in high doses. Therefore, post cycle therapy is often recommended after a SARMs cycle to help the body recover its natural testosterone levels (source) whereas MK-677 typically doesn’t require a PCT.

Reason 4: Regulatory Status

When it comes to regulatory status, MK-677 Ibutamoren and SARMs are in different leagues. MK-677 is an investigational drug, which means it’s still being studied for its safety and efficacy. However, it’s not approved by the FDA or any other health authority for medical use. It’s legally sold as a research chemical, not a dietary supplement (source). Check out various MK-677 brands in the market.

SARMs, on the other hand, are in a murkier legal area. They’re not approved by the FDA for medical use, and the FDA has issued warnings about them due to potential side effects like liver damage and cardiovascular risks. They’re often sold online as “research chemicals,” but the FDA has cracked down on companies marketing them as dietary supplements (source).

Reason 5: Different Impact on Hormone Levels

MK-677 Ibutamoren and SARMs also have different impacts on hormone levels. MK-677 increases the levels of growth hormone and IGF-1 in the body without affecting other hormones like cortisol. This is a significant advantage for those who want to avoid the hormonal imbalance associated with other performance-enhancing drugs (source).

SARMs, however, can suppress natural testosterone production with prolonged use. This can lead to side effects like fatigue, mood changes, and loss of libido. Post cycle therapy is often recommended after a SARMs cycle to help the body recover its natural testosterone levels (source).

Reason 6: Usage and Dosage Differences

When it comes to usage and dosage, MK-677 Ibutamoren and SARMs differ as well. MK-677 is usually taken orally once a day, with a common dosage being 10–25 mg per day. It’s also known for its long half-life, which means it remains effective in the body for a longer period (source).

SARMs, on the other hand, have a shorter half-life and are usually taken in cycles. The dosage can vary widely depending on the specific SARM, but it’s generally recommended to start with a lower dose and gradually increase if necessary (source).

Reason 7: Different Results and Expectations

Finally, let’s talk about results and expectations. MK-677 Ibutamoren is known for promoting lean body mass, boosting muscular strength, and improving sleep, skin, and hair quality. It’s a long-term game, with noticeable results often taking several weeks to months.

SARMs, however, are often used for shorter, more intense cycles. They can promote rapid muscle growth and fat loss, but they also come with a higher risk of side effects. The results can vary widely depending on the specific SARM and the individual’s body chemistry.

Conclusion

So, is MK-677 a SARM? Technically, no. It’s actually classified as a growth hormone secretagogue, which means it stimulates the secretion of growth hormone. However, because of its muscle-building effects, it’s often grouped with SARMs in discussions about performance-enhancing substances. While MK-677 does share some similarities with SARMs, it’s not a SARM in the traditional sense. It’s a unique substance with its own set of benefits and potential risks.

As we’ve journeyed through the world of MK-677 Ibutamoren and SARMs, we’ve uncovered some fascinating truths. Despite their similar benefits and target audience, these two are fundamentally different in their chemical structure, mechanism of action, side effects, regulatory status, impact on hormone levels, usage, dosage, and expected results.

MK-677 Ibutamoren, a growth hormone secretagogue, mimics the hormone ghrelin and increases the secretion of growth hormone and IGF-1. It’s known for its long-term benefits like promoting lean body mass, boosting muscular strength, and improving sleep, skin, and hair quality. It’s also noteworthy for its minimal impact on other hormones and its long half-life.

On the other hand, SARMs, as selective androgen receptor modulators, bind to androgen receptors in different tissues, promoting muscle growth and fat loss. However, they come with potential side effects like testosterone suppression and liver damage, and their legal status is a bit murky.

In the end, whether you choose MK-677 Ibutamoren, a SARM, or any other supplement, it’s crucial to do your research, understand the potential benefits and risks, and use them responsibly. Remember, there’s no magic pill for fitness — it’s a journey of hard work, dedication, and smart choices.

About the author

Andy Rogers is a fervent biohacker and an accomplished engineer. His expertise in the Digital Marketing realm spans over 8 years, giving him a profound comprehension of the nexus between technology, health, and human performance. His fascination with biohacking is driven by an ambition to maximize every aspect of human existence. Andy is a strong advocate for the use of herbs, PEDs and other substances to boost performance, whether it’s in a corporate setting, physical fitness, or daily life. He is perpetually on a quest to discover and experiment with innovative methods to expand the limits of human capabilities.

Andy’s biohacking methodology is deeply influenced by his engineering background. He employs the same strategies of troubleshooting and enhancement to his personal health and performance. This has propelled him to explore extensively into the realm of Performance Enhancing Drugs (PEDs), gaining insights into their potential advantages for performance enhancement, injury recuperation, and disseminating this information to others.

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Andy
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