Monoclonal Antibody Production
Monoclonal antibody therapeutics are rapidly evolving on a global scale. From PD to commercial production, Bio-Link reduces costs and increases efficiency for your monoclonal antibody production platform.
A classic antibody production process typically comprises of two major stages:
Upstream cell culture
Downstream purification
At different stages of the classic production process of producing monoclonal antibodies, Bio-Link is capable of offering our customers reliable and efficient bioprocessing equipment and consumable solutions, ranging from single use bioreactors to chromatography resins, for their needs.
Bio-Link offers a range of solutions for cell culture processes for monoclonal antibody production, including:
Single use wave bioreactors
Single use stirred-tank bioreactors
Cell culture bags (with customizable options)
Microcarriers for suspension culture
Protein Purification
The downstream purification performance often directly affects the yield of bioprocess batches, and thus indirectly determines their cost and price. Bio-Link is capable of providing comprehensive, robust, and cost-effective protein purification solutions for biopharmaceutical companies.
The three-step chromatography process is a common method for downstream purification of monoclonal antibodies. In Bio-Link’s solution, MaXtar ARPA affinity chromatography can be used to efficiently capture monoclonal antibodies and remove a large amount of HCP, fragments, viruses, HCD, and medium components through specific binding. Then, MaXtar Q anion exchange chromatography can be used to further purify the monoclonal antibody through a flow-through mode, which not only removes impurities such as proteins, aggregates, and endotoxins, but most importantly, removes viruses. Finally, MaXtar SP HR cation exchange chromatography can be used to remove impurities by a bind-and-elute mode, further removing HCP, shed Protein A, aggregates, fragments, and other isoforms.
Bio-Link offers a complete range of chromatography resins:
Size Exclusion Chromatography
Ion Exchange Chromatography
Affinity Chromatography
Hydrophobic Interaction Chromatography
Multimodal Chromatography
Polymer Chromatography
In addition, Bio-Link is able to provide chromatography columns of different specifications for your antibody production needs, including small-scale laboratory development columns, pre-packed columns, and industrial-grade columns for large-scale commercial production.
Single-use Fluid Management
Bio-Link offers a range of fluid management solutions for biopharmaceutical processes, including preparation, storage, transfer, and mixing of solutions.
For more information about current trends in monoclonal antibody development and manufacturing ,please feel free to contact us!
There are many bioprocessing companies, but we are one of the best choices for you.
