Passive immunotherapy of Aids has proven to be effective on animals
An US research team reports that they have developed a therapy which protects the monkey against the simian version of the AIDS virus (SHIV) infection in the last six-month period with a single injection. The study has important implications for the prevention of HIV transmission in high-risk groups.
Passive immunization hepatitis provides protection in the months before an effective vaccine to humans. Previous studies have found that if animals exposed to high doses of virus before obtaining HIV-1 virus antibody 1–2 days, but also to show the ability to block virus infection. But the long-term effectiveness of this passive immunotherapy has not been confirmed by experiment.
The new study, the US National Institute of Allergy and Infectious Diseases Malcolm .A • Martin and his colleagues hope to solve this problem, to confirm hepatitis A similar passive immunotherapy can continue to work in the anti-HIV infections .
The researchers published the papers in the Journal Nature saying that they control group of nine macaques simulates the way humans infected with HIV, the average time to detect infection in three weeks. Then they injected three different antibodies to each of the three groups of six animals, and they are exposed to the virus in the week. The results showed that all groups receiving antibody viral infection time were delayed; the longest protection period lasted 23 weeks, the duration of protection directly related to the antibody half-life and strength. They also found that, by the introduction of amino acid variation in methods to extend the effectiveness of the weakest antibody half-life.
The researchers said that such antibodies can improve their overall spread ability to block HIV-1 drug-resistant strain of the virus, providing a proof of concept for the prevention and treatment of HIV-1 virus. However, more research is needed to confirm the effectiveness of this therapy on humans and whether it can replace HIV-1 vaccine.
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