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Muse definitely makes sense sometimes, but if you want anything with more functionality than simply clicking buttons, something like a CMS or e-commerce site then Wordpress is absolutely the way to go, you can even charge the clients for the apparent huge loss of money on maintenance.

You forgot an important part about Muse, though. With Muse you must make every change for the user, there is no way to add a CMS system unless you also subscribe to Adobe business catalyst, but this still doesn’t let you use things like blogs or e-commerce.