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Oral doses of THC range from 2.5 to 20 milligrams for therapeutic purposes. A regular joint (1 gram of 2.5% leaf or 0.5 grams of 5% higher-grade leaf) usually has 25 milligrams of THC. Over half of this amount is generally destroyed by combustion or is lost in side-stream smoke. Around 15 to 50% of the THC in a typical marijuana joint actually gets to the bloodstream, making the actual inhaled dose closer to 3 to 12 milligrams.

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THC will not naturally occur in its active form in the cannabis plant. Instead, it occurs in an acidic form called tetrahydrocannabinol acid or THC acid (THCA). When burned in a cigarette or heated in cooking, the THCA is rapidly converted to active THC in a heat-propelled reaction called decarboxylation. Unlike THC, we have very little knowledge of THCA. We do know that it is not psychoactive, but it has been discovered to have immune-modulatory properties akin to other cannabinoids.

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Eating marijuana raw will not produce any strong psychoactive effects because the THCA is essentially inactive. As marijuana ages, however, some of the THCA undergoes decarboxylation. The marijuana resin in hashish usually contains very high levels of active THC.

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