What a great example of making a technical document more accessible through design. Medical documentation is another area ripe for design overhaul, from the page layout to font selection to language simplification/clarification.
I also like the idea of combining hyperlinks, footnotes, and color-coding. I’m not sure if the color-coding and underlining in the example was intended to just point out the changes that were made, or if the underlined blue words were meant to be actual hyperlinks. However, given the high likelihood that many documents will be interacted with via touchscreen, all of these elements could be judiciously utilized for greater readability (pun somewhat intended). Footnotes for immediate access, hyperlinks for ease of navigation (within the document and to supporting documents, such as definitions or precedence) and longer notes, and color-coding for emphasis/speed when scanning.