T-blockers (testosterone blockers) are extremely important in transitioning. They’re also called anti-androgens. For many transgender women, they alleviate dysphoria and help in feminization. Currently, in the united states, the most prescribed anti-androgen is spironolactone. However, spiro is not the most effective. It is, however, tolerated and safe for many transgender women. Hence, its use. Big disclaimer: I am not a chemist or pharmacist. I am a medical student with so much research interest. It is important to always discuss with your doctor your transition goals and to read this article to gain knowledge, not as a standard of practice. Please check with your doctor for more information if you need help choosing the right testosterone blocker. In this article, I compare anti-androgens.