Zoloft was too deadening for me. I tried several others, but ended up with Effexor at a low dose. To make it work I have to be a bit life-style cautious.

1) no street drugs or alcohol

2) daily exercise

3) steer clear of drama, especially people who like to create drama

Best of luck — depression is a hard. Anti-depressants are a drag, but better than self-destructive choices