What if you could grow your own insulin at home?

Installation for ‘Everything Happens so Much’ in London College of Communication, part of London Design Festival 2018 © Carlos Canali

Plant Molecular ‘pharming’ (portmanteau of ‘farming’ and ‘pharmaceuticals’) or ‘farming’ is the process of genetically modifying plants to make useful drugs. This technology uses plants to produce large amounts of pharmaceutical substances such as vaccines and antibodies. It relies on the same method used to produce genetically modified crops, namely the artificial introduction of genes into plants. Successful products derived from this practice include human haemoglobin, the ebola vaccine Zmapp, influenza vaccines and a colon cancer antigen, among others.

During ‘Everything Happens so Much’, an exhibition held at London College of Communication and part of London Design Festival 2018, three MA students from Service Experience and Interaction Design created an installation to probe people’s reactions to the question:

What if you could grow your own insulin at home?

It is September of 2030. A kitchen counter provokes the audience into considering the possibilities of growing pharmaceutical substances at home. They can examine a number of speculative objects, which build a narrative that starts in the mid-80s. The narrative is based on the entrepreneurial experience of Arman Moridi, an Iranian molecular scientist, and presents a home space where we can grow insulin by means of plant molecular pharming technologies. A number of industrial objects have been developed by the bioscience company Moridi Farma. These allow us to access technologies currently in the realm of research laboratories or biohacker communities.

In the kitchen, the BioOven 5000 can perform a Polymerase Chain Reaction (PCR), has an Incubator Shaker and includes an Electroporation function. You can also heat, grill or defrost food. A product called HomeGrown Insulin rests on the counter. It is accessible for home delivery, in a small box with simple instructions. With it, you can grow an Australian tobacco plant widely used in plant molecular pharming and infiltrate it with a plasmid containing your gene of interest, in this case the insulin gene (INS). Then, within two to three weeks, you will be able to ‘harvest’ your insulin. Also on the counter, a September 2030 edition of Bioscience magazine weaves the story of the different speculative objects on display by means of a timeline and a featured article.

A number of enablers make the scenario possible, such as deregulation of medicine production and the development of hybrid home-lab equipment for personal use. Also, a critical product has been developed: HomeGrown Insulin.

Medical De-Regulation Act of 2020

In a timeline interweaving reality and fiction, we discover how shortages of medicines, resulting from a no-deal Brexit, led the UK Government to deregulate the market for pharmaceutical products. Arman Moridi, a London-based exile of the 2019 US-Iran Crisis, provides the scientific nous and business drive to launch a business that thrives on this deregulation.

As a result, HomeGrown Insulin and the BioOven 5000 occupy their functional (and fictional) context in the kitchen. In another corner of the counter, wooden spoons, a whisk or a bowl of apples rest calmly alongside pipettes, syringes, test tubes filled with plasmids and petri dishes in which plants, currently domesticated mainy in labs, peacefully germinate.

Accessibility and new delivery models

While some scientific aspects remain unsolved in 2018 (e.g. dosage or purification), the installation raises questions on the status quo in manufacture and delivery models for everyday medicines.

Although the use-case is based in the UK, it also raises issues around access to critical drugs in low income countries. This is relevant, as in these markets, the impact of molecular pharming could increase as the platforms are standardized and optimized for clinical development. This would offer new opportunities to produce inexpensive medicines in regions that are typically excluded by current business models.

Feedback from visitors to the installation was positive. A medical student, while understanding towards the limitations regarding dosage, was positive about near future applications for drugs where dosage is not a big issue. A bioscientist at the launch party suggested the use of this kind of speculation for engagement with publics in other contexts outside design schools, such as biochemistry conferences or outreach events to engage non-scientific audiences with biosciences. Overall, visitors at the installation were at once intrigued, accepting and curious about the possibilities and feasibility of the situation presented to them.

Background

The installation has been conceived and executed by Carlos Canali, Clara Llamas (MA Service Experience Design and Innovation) and Michael Sedbon (MA Interaction Design). They are doing their master’s degrees final submissions within the context of Pharma Factory, a H2020 research project in which London College of Communication is a partner. All three have conducted ethnographic work at St George’s University, also a project partner, working alongside molecular biologists, biochemists, virologists and immunologists to better understand the context and technologies.

Pharma Factory is a research project conceived by molecular pharming companies and researchers, to advance medical, veterinary and diagnostic products. It aims to maximise impact by engaging with all stakeholders from scientists to government and the public at large, developing new tools to facilitate communication and help reduce barriers to acceptance.

Diegetic objects and real object captions

Front and back covers of Bioscience magazine, edition of September 18–23 of 2030
Article on Arman Moridi and Moridi Farma and timeline of events leading up to HomeGrown Insulin

Bioscience Mag (September 2030)

Bioscience is a holo-printed consumer magazine for anyone interested in the home production of pharmaceuticals. It has a readership of 15 million in the United Kingdom and a US edition. The September 18–23, 2030 copy on display features the story of Arman Moridi, founder of Moridi Farma and a key character making this kitchen lab installation possible.

By 2030, the company product HomeGrown Insulin has topped £250 million in sales revenues. The company is ready for international expansion. The magazine also describes a timeline of events surrounding the company, accounting for external factors, such as the US-Iran Crisis of 2019 and the 2020 Act of Medical De-Regulation in the UK.

BioOven 5000 by Moridi Farma

BioOven 5000 by Moridi Farma & Xarsung

A hybrid oven developed by Moridi Farma with Xarsung Electronics. It has the functions of a microwave, as well as functions for tasks traditionally used in molecular biology labs

  • Polymerase Chain Reaction (aka PCR) is a common laboratory technique used to make many copies (millions or billions) of a particular region of DNA. This is achieved in a series of temperature changes. It is routinely used in DNA cloning, medical diagnostics, and forensic DNA analysis.
  • The Incubator Shaker function helps create the optimal conditions for cell growth by providing the agitation or shaking necessary to incorporate oxygen and evenly distribute nutrients throughout the culture media.
  • Electroporation is a microbiology technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane. This makes it possible for chemicals, drugs, or DNA to be introduced into a cell. Electroporation helps BioOven 5000 users with the introduction of foreign genes into tissue culture cells while manufacturing their medicines.
Package and instructions of the product HomeGrown Insulin by Moridi Farma

HomeGrown Insulin Kit by Moridi Farma

HomeGrown Insulin is Moridi Farma’s flagship product. It is designed for the home manufacturing of insulin and has a customer base of two million users in the United Kingdom. 
The product is displayed here and works best when used in combination with the BioOven 5000, also manufactured by Moridi Farma and developed in collaboration with Xarsung Electronics.

The product package and instructions on display reflect the ease of use for home consumers. They can have a de-stressing experience growing their own plants and subsequently use them as bioreactors to produce their own insulin. In 2030, manufacturing insulin inside plants, in the peace and quiet of your home kitchen, is a reality.

Nicotiana benthamiana © btiscience.org

Tobacco Plants (Nicotiana Benthamiana)

Nicotiana benthamiana is a close relative of tobacco and a species indigenous to Australia. It was used by people of Australia as a stimulant, since it contains nicotine, before the introduction of commercial tobacco (Nicotiana tabacum and rustica). Due to the large number of plant pathogens able to infect it, Nicotiana benthamiana is widely used in the field of plant virology. It is also an excellent target plant for agroinfiltration. This is a method used in plant biology to induce transient expression of genes in a plant and produce a desired protein.

Nicotiana benthamiana is also an excellent platform, or bioreactor, for the industrial production of pharmaceutical proteins and antibodies that may be used in medicines. Normally, animal or microbial cell cultures are used to produce vaccines. However, the costs associated with maintenance, safety, storage and transport are reported to be sometimes as much as 80% higher than using plant-derived alternatives such as Nicotiana benthamiana.