…, impaired mobility” and other characteristics similar to osteoarthritis. So clearing out senescent cells improves health, and adding them in causes health problems. The challenge now, which is large, is to figure out whether the findings in animals can safely translate to treatments for humans.
… a causal connection between senescent cells and the issues of aging — scientists, led by Kirkland, have come up ways to clear out senescent cells using compounds called senolytics, which have demonstrated profound health benefits in a lab setting. Clearing out senescent cells improves heart function, decreases frailty, alleviates radiation-induced damage, alleviates idiopathic pulmonary fibrosis and improves respiratory function, alleviates cirrhosis caused by high fat feeding (now the most common form of cirrhosis, over alcohol), and prevents and partly reverses age-related osteoporosis in mice.