David Barker: Certainly, without enough calories, one can’t get fat. Nothing about the CIM violates the laws of thermodynamics. But it’s potentially more than just how many calories you can …. eat. If metabolism decreases less following weight loss on a lower carbohydrate diet, it likely indicates that the effective body weight “set-point” has decreased, that these is less biological pushback. This supposition is supported by preliminary evidence that hunger is also decreased with carbohydrate restriction. The upshot is that weight loss maintenance, the home run of obesity treatment, may be easier for multiple mutually synergistic reasons. Of course, more research is needed to test these hypotheses.