The ideas with which I grew up, a la Werner Von Braun and Walt Disney, would have avoided many of the health problems encountered with the ISS. Even Ezekiel saw a wheel :-)
The main problem on Mars will be radiation. The earth’s magnetic field steers all those particles to the poles for nice light shows and leaves us alone. Lack of such a magnetic field is what destroyed the Martian environment and any (hope for) life there.