Omega 3, Bacterial Flora and Behavior

The presence of Omega 3 in the diet has neuro pathological consequences

In both mice and humans, brain growth and development begins in the early postnatal period. This occurs together with the development of the intestinal microbiota. Aninterdependencebetweenthesetwoprocessesissuspected. Weal so know that omega-3 polyunsaturated fatty acids are structural and essential components of the developing brain.

The first three years of life (of humans) represent the most critical period. Can diet aryinterventionsaimed at modulating the micro bio ta positively affect health in adulthood?

Little is known about the relation ship between the intake of maternal Omega 3 and that of the first years of life on the development of the intestinal microbiota and its interactions with behavior

The experiment

One study has found that the neuro behavioral changes induced by stress and Omega 3 tests are closely linked with the microbialcomposition and inflammation in mice.

The researchers examined the effects of Omega 3 deficiencyon depressive, cognitive and social behaviors during adolescence and adulthood in mice. They examined correlations within flammatory results, hypothalamic-pituitary-adrenal axis activity and alterations in the development of intestinal microbiota.

Threegroups of 10 pregnantfemales and their offspringweremade. Theywerefed a standard control food, an omega-3 deficientdietor a dietsupplementedwith omega-3. Through a battery of behavioraltests in males, the behaviorswereevaluated. Thesetestswereperformedboth in adolescence (week 4–5) and in adulthood (week 11–13). Activation of the hypothalamic-pituitary-adrenal axis wasassessed by the analysis of the production of stress-inducedcorticosterone. The fecal microbiotacompositionwasanalyzed by 16S sequencing in bothadolescence and adulthood. In addition, stimulatedlevels of cytokines in the spleen wereevaluated.


Thus the results are veryevident in adulthood. Mice deficient in omega-3s hadimpaired communication and social behaviors, as well as behaviorrelated to depression.

By stimulation of the spleen withConcavalin A and lipopolysaccharide, inflammationwasmeasured. Micewith the omega-3 deficientdietexperienced a significantdecrease in tumor necrosis factor and interleukin 10. Thissignificancewasfulfilledboth in comparison to the controls and foreach of the compounds.

Neurobehavioralchanges in thesemicewerecloselyassociatedwithchanges in the composition of the intestinal microbiota. Theydeveloped a highproportionFirmicutes-Bacteroidetes. In contrast, omega-3-fed miceshowedincreased fecal abundance of Bifidobacterium and Lactobacillus. Thischangecushioned the activity of the Hypothalamic-Hypophyseal-Adrenal axis understressfulconditions.

Theseresultsdemonstratethatdietaryintervention, particularlywith omega-3s, mayhaveanimpactonbehavioraloutcomes and could be mediated by the intestinal-microbiota-brain axis.

As summaryWehave

The neuroethologicalchangesobserved in adolescence and in adulthoodinduced by omega-3 deficiency are closelyrelated to alterations in the composition of the intestinal microbiota, the activity of the Hypothalamic-Pituitary-adrenal axis and inflammation. These data suggestthatbehavioralresults are triggered by omega-3s may be related to changes in the intestinal microbiota.

Ideally, fish and seedsshould be part of our regular diet. Salmon, sardines, tuna, and mollusks are the richestanimals in omega 3. You can alsogetit in a smallerproportion of eggyolk and seafood. Butnotonly do theyexist in the animal kingdom, the personwhowants vegetable omega 3 shouldusuallyincludenuts, flaxseeds, chiaorhemp and wheat, soybeanorcorngermoils. You can alsogetit in a lowerproportion of chickpeas, almonds, cabbage, spinach, cucumbers, strawberries …

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