Relax. Don’t Do it.-Frankie goes to Hollywood

Heyyo to my fellow bloggers! So I’m going to take this blog down a notch from my usual comedic post, and get a bit serious…

A lot of the time, people will tell someone else “to relax”, or “just don’t think about it”. Well I’m here to tell those people to just shut up. I am one of the many people that suffer from anxiety. For me anxiety can come for no reason. I have often times have had light headedness, rapid heart rate, numbness and the struggle to breath normally. Anxiety is something that can control someones life. And for those who suffer from anxiety, hopefully the information I give you today can be useful to you in any shape or form.

According to the research paper Emerging Drugs for the Treatment of Anxiety, anxiety is the most disabling disorder worldwide. 1 in 4 people will have this disorder in their lives. These people will have symptoms of physical or mental discomfort and maybe both. The symptoms can lead to depression or bipolar disorder. They can be classified as “separation anxiety disorder, selective mutism, specific phobia (SP), social anxiety disorder (SAD), panic disorder, agoraphobia, posttraumatic stress disorder (PTSD) and obsessive compulsive disorder (OCD), generalized anxiety disorder (GAD), substance/medication-induced anxiety disorder and anxiety disorder due to another medication condition.”

All together psychologist have a hard time classifying the different anxiety disorders for most cases. This makes it harder for them to prescribe the right medication. When psychologist prescribe medication for anxiety there is a “First line Treatment” which is what they would try first; and a “Second line Treatment”, which is the second option, due to safety reasons.

  • First line Treatment: SNRIs help in the re-uptake of SSRIs and serotonin norepinephrine. Psychologist use it for treatment of GAD, SAD, panic disorder and PTSD.
  • Second Line Treatment: Tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) help with anxiety as well but it has been seen that long term use could result in depression. The body also does not adapt well to these drugs.

Psychologist are still looking into new drugs that could help anxiety without harm.

  • Vortioxetine: a serotonergic compound, that is serotonin transporter (SERT) inhibitor to the 5-HT1A receptor. It increases serotonin, dopamine, noradrenaline, acetylcholine and histamine in the prefrontal cortex and hippocampus.
  • Noradrenergic hyperactivity is seen to be a critical component to stress and anxiety. The high catecholamine during stress can impair PFC functions. Guanfacine is a noradrenergic alpha-2 receptor that can reduce noradrenergic signaling, thus reducing the anxiety.
  • Pregabalin, 3-isobutyl-GABA: It is a drug binds to the alpha-2-beta subunit, on the calcium voltage gated ion channel to reduce release of Calcium ions, and thus releasing glutamate and norepinephrine into the synaptic cleft.

As of right now, there are not many medicines that can help with the anxiety, but there are a lot more chemical molecules like above, that are being researched in link to anxiety to know what causes it and how can we block it. Hopefully one day people with anxiety can live a normal life.

References

Murrough, James W. et al. “Emerging Drugs for the Treatment of Anxiety.” Expert opinion on emerging drugs 20.3 (2015): 393–406. PMC. Web. 31 Oct. 2016.

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