The convo takes place between 3:38 - 5:32. The transcript is below.

Seth MacFarlane: My Twitter -- since I made the announcement [of my book] -- has been full of people just tweeting, 'Hey, how's that novel coming, my friend?'

Jon Stewart: (Laughter)

MacFarlane: ...which I should have anticipated... So I made my own bed and now I have to shi* in it.

Stewart: I have to get a Twitter account... How long have you done the Twitter account?

MacFarlane: Oh, god, it seems like a hundred years. Do you do Twitter? You have a Twitter [or] your show has a Twitter.

Stewart: I have not yet. I'm waiting to see how it works out. Will it catch on?

MacFarlane: Yeah. I don't know anyone who has Twitter who's not sick to death of Twitter.

Stewart: It seems like something always over your head.

MacFarlane: We all want it to go away. We're all sick. And you see dignified actors and actresses who are now getting into these Twitter arguments with people, and you look like a jackass on Twitter so easily.

Stewart: But it's also, I would imagine, it's always pressure... One of the nice things about when we're not taping the show is I don't have to think of anything interesting, but if you have this Twitter account it is a constant group of people who are just sitting like this: [places elbows on table, hands under cheeks]

MacFarlane: You're smarter than the rest of us because in the beginning, you're like, 'A joke a day? That's fun.' And then you're like, 'Oh shi*, a joke a day... and for free.'

Stewart: Do they yell at you on there? Have you gotten into fights?

MacFarlane: Yeah, you'll get responses like, 'Meh, not your best.' It's like, 'This is free, you bastard, you're not paying for this'

Stewart: Can you imagine somebody coming and not paying money and still frowning? [stares at audience]

MacFarlane: I can't imagine that. (crowd laughter)