Endocannabinoid system: Role in depression, reward and pain control (Review).

Clinical studies revealed altered endocannabinoid signaling in patients with chronic pain. Considerable evidence suggested the involvement of the endocannabinoid system in eliciting potent effects on neurotransmission, neuroendocrine, and inflammatory processes, which are known to be deranged in depression and chronic pain.

Link to the full text: http://www.ncbi.nlm.nih.gov/pubmed/27484193