Great article, but I have one caveat. Guidelines are not just about the best science. Just as medicine more generally is as much an art as a science, guidelines should reflect humane and ethical concerns as well as scientific ones. Seems like a lot of these issues — COI, entrenched ideologies, as well as the tendency for guidelines to treat people as bags of biochemistry or statistical humans — might be addressed by having a bioethicist (or two) on every guidelines committee. And btw, in term of COI, I’m not a bioethicist.