A Closer Look at the Incredible Potential of Molecular Machines

Foresight Institute
5 min readJul 14, 2023

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By Beatrice Erkers, Foresight Institute

Just as we’ve built machines to help us move and shape the large-scale world around us, scientists are working on machines so tiny they function on the molecular level — and this could truly change everything. Just like a car engine or a windmill, these tiny machines, known as “molecular machines,” can take energy and use it to do work, but they do it on a scale that is incredibly small — less than the thickness of a human hair. This work could revolutionize everything from medicine to how we build things.

This picture shows an early vision of what Molecular Machines can help us do some day. “Several billion dermal display nanorobots residing in the epidermis of a human hand can be used as display screens to access real-time physiological information or other stored data, as described by Robert Freitas in Section 7.4.6.7 of Nanomedicine, Vol. I. In this third of four images, the fully visible dermal display screen (in background) shows a clear representation of the concentration and kinds of in vivo nanorobots, to the approval of the user (in foreground)”. © Copyright 1999 by Tim Fonseca. From Foresight Insitute’s old Nanomedicine art gallery.

So, what exactly are these molecular machines? In simple terms, they are extremely tiny devices, designed by scientists, that can do a job of some kind. That job could be as simple as moving a molecule from one place to another or as complex as building other molecules. The amazing thing is that they do this at the nanoscale — a scale so small that we can’t see it with the naked eye. For reference, a nanometer is one billionth of a meter!

There are many ways these tiny machines could help us in the future. In medicine, we could use them to deliver medicine directly to the cells that are sick. This would make the medicine much more effective and could reduce the negative side effects. In other areas, like material science, we could use these machines to create materials that can change their properties as needed or even fix themselves when they are damaged. Imagine a scratch on your car fixing itself, or a cracked window in your house healing like a wound!

The possibilities of what we can achieve with molecular machines are only just beginning to be explored. As we learn more and more about how to build and use them, we could start to see them being used in all sorts of ways in our everyday life. They could be a major part of the future of technology, changing how we treat diseases, how we build things, and so much more. It’s been said that we’re at the very start of a new spring — a “nanotechnology spring” — and it’s a very exciting time.

FAQ: Molecular Machines and Nanotechnology

What are molecular machines?

Molecular machines are tiny devices constructed at the molecular or nanoscale that can perform specific tasks or functions. They are built using individual molecules or molecular components and are designed to manipulate and control matter at an extremely small scale.

How do molecular machines work?

Molecular machines operate by utilizing various mechanisms such as molecular motors, switches, or sensors. These mechanisms can be powered by external stimuli such as light, heat, or chemical reactions, allowing the machines to perform specific actions, such as movement, assembly, or chemical transformations.

What is nanotechnology?

Nanotechnology is a multidisciplinary field of science and engineering that focuses on the manipulation and control of matter at the nanoscale. It involves designing and building structures, devices, and systems with precise control over their properties and functions at the nanometer level.

What is the relationship between molecular machines and nanotechnology?

Molecular machines are an integral part of nanotechnology. They are considered one of the key building blocks of nanoscale systems and play a crucial role in the development of nanotechnology applications. Molecular machines enable the precise control and manipulation of materials and processes at the molecular or nanoscale.

What are the potential applications of molecular machines and nanotechnology?

Molecular machines and nanotechnology have vast potential across various fields. In medicine, they could enable targeted drug delivery, diagnostics, and advanced imaging techniques. In electronics, they could contribute to the development of smaller, more efficient devices. Additionally, nanotechnology has applications in energy, materials science, environmental remediation, and many other areas.

Are there any risks associated with nanotechnology and molecular machines?

As with any emerging technology, there are potential risks and concerns associated with nanotechnology and molecular machines. These may include unintended environmental impacts, ethical considerations, and potential health effects. It is important that scientists and researchers actively work to understand and mitigate these risks through responsible development and rigorous safety assessments. Ideally using a differential technology development approach.

How advanced is the current state of molecular machines and nanotechnology?

The field of molecular machines and nanotechnology has seen significant advancements. Scientists have successfully constructed various types of molecular machines, including molecular motors and sensors, and nanotechnology has led to the development of many functional nanomaterials and devices.

For example, nanotechnology is used in everyday items like sunscreens, which often contain nanoparticles of zinc oxide or titanium dioxide to provide better UV protection. It’s also integrated into clothing fabrics for stain and water resistance, and in electronics like smartphones and laptops, where nanoscale transistors offer faster processing and reduced power consumption.

However, molecular machines are still mostly in the research and development stage.

Foresight Institute’s work on Molecular Machines

The Foresight Institute brings together people to work on developing these molecular machines. We do this by:

  • Hosting our Molecular Machines technical group where we connect scientists, entrepreneurs, and institutional allies who cooperate to advance nanotech and molecular machines
  • Seminar summaries and Youtube channel: We share new videos as well as written summaries of the work discussed in our technical groups
  • Hosting technical conferences where we invite top researchers, entrepreneurs, and funders to highlight undervalued areas for progress, and forming lasting collaborations with other actors around shared goals
  • In our Molecular Machines Tech Tree we map ambitious goals in nanotech to help new talent and funders understand how they can help advance this field. By accessing this public map, individuals can glean the current status quo of the field, its future, pinpoint key actors, understand technical capabilities and limitations, its challenges, bottlenecks, and impact areas. All to see if we can revolutionize technology by progressing nanotech toward Atomically Precise Manufacturing.
  • Our Feynman Prizes are named in honor of the physicist Richard Feynman. In 1959, Feynman gave a talk titled ‘There’s Plenty Of Room At The Bottom’, which is considered by many industry advocates to have inspired the field of nanotechnology itself. With the Feynman Prizes, Foresight Institute wishes to recognize recent and brilliant achievements that contribute deeply to the field of Nanotechnology. The Feynman Prize honors outstanding work early: In 2016, Sir J. Frazer Stoddart shared the Nobel Prize in Chemistry for the design and synthesis of molecular machines.This was only nine years after he received Foresight’s Feynman Prize in Experiment!
  • The Foresight Fellowship is a one-year program committed to giving change-makers the support to accelerate their bold ideas into the future. Our mission is to catalyze collaboration among leading young scientists, engineers, and innovators who work to advance technologies for the benefit of life, such as nanotech and molecular machines.

If you’re curious about Foresight Institute, visit our website https://foresight.org/ to learn more about any of our focus areas:

  1. Molecular Machines to better control matter
  2. Biotech to reverse aging
  3. Computer Science to secure human AI cooperation
  4. Neurotech to support human flourishing
  5. Spacetech to further exploration
  6. Existential Hope to ask what future we want to create

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Foresight Institute

Foresight Institute is a 501© 3 non-profit foundation for world-shaping technologies. We support technological developments towards an abundant future.