Cytoskeleton Op. Ed.
The Cytoskeleton is made up of filamentous proteins and gives the cell its structure and is a key component in allowing the cell to divide, without the Cytoskeleton the cell would not be able to maintain its structure and as a result the cell and its host would die. Not only does the Cytoskeleton provide the cells structure but it is the sole reason that the cell is even allowed to move. The cytoskeleton provides the cell with contractile movement through many proteins that make up the cytoskeleton more specifically cilia and flagella move due to microtubules in the Cytoskeleton rubbing together and propelling the cell forward. some viruses are transported to the cell nucleus along microtubules, a component of the cytoskeleton. There is some evidence that in Alzheimer’s disease microtubules in nerve axons are lost and that tangled protein increases. Microtubules found in nerve cells are attached to microtubule associated proteins (MAPs) including tau protein. In healthy cells these proteins are attached to the outside of microtubules. In Alzheimer’s disease and some other dementias microtubules are lost from the axons and there is an increase in unorganised tangled filaments of tau protein. Nerve axon are nerve proteins that reside in nerve cells (the cells that make up our sensitive nerves in our brain) The loss of microtubules results in the loss of a transport service up and down the nerve axon. Without this movement of biochemicals and organelles the nerve cell loses function. Essentially an increase in tau proteins lead to microtubule failure and as microtubules fail it becomes harder for these nerve axons to read and interpret signals effectively weakening them and opening up the door for Alzheimer’s disease to infect the cell.