Speaking as someone with a background in computer science and physics, I find the simulation hypothesis unconvincing. In physics terms, we are uncovering steadily more complex layers of reality as we move out from our baseline scales: Compare Newtonian mechanics to quantum field theory for a moment, and you see a starting level of difference. This keeps increasing, it seems, leaving nowhere for the bones of the simulation to be, nowhere for the necessary abstractions demanded by computer science.
Then of course there’s the metaphysics of it: If we are living in a simulation that so totally models the ‘real’ world, what, precisely, is the difference to this supposed real world? What is fundamentally different for us? In the end, it just boils down to a nerdy sort of belief in Heaven. If you’re sufficiently pious and do the right things you will be rewarded in the afterlife. As an atheist and humanist, I have no use for that notion.