Maybe. But I doubt many in the states left behind would want to fight and maybe die to keep states and a culture they dislike in the union. There was a strong peace faction in the North and if slavery had not existed, I think it would have done very well. Plus if the path of secession — I call it “divorce over reconcilable differences” — is done nonviolently, that increases the likelihood of it being peaceful. Finally, what with Brexit and with at least one democracy dividing peacefully (Czechoslovakia) it’s more legitimate than it once was.
Practically speaking perhaps the best that might happen is if the states become more independent of one another bit by bit until some place is found where all sides are reasonably comfortable.
But the right wingers far more than the liberals and progressives are upping the ante to the point where the union will no longer be viable. The Garland/Gorsuch episode, and what McConnell said he’s do if Clinton won, proves one group absolutely will not honor the constitutional rights of the other. That will not work for the long run.