Genetic study provides clues to treat Huntington’s disease
A new approach to investigating factors that affect the onset of symptoms of Huntington’s disease (HD) has identified a couple of genome sites where variants that can speed-up or delay symptom onset can be found.
The team of researchers analyzed more than 4,000 gene samples from HD patients. They found that particular variants on two chromosomes were more common in individuals who showed symptoms of HD-like movement disorders either earlier or later than would normally have been expected.
In earlier studies to find ways of delaying the onset of HD symptoms, the researchers focused on studying the mutant protein in cells or in animal models. But the limitation of those studies was that the relevance of abnormalities found in animals to what actually happens in patients was largely an assumption.