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Not since this author’s bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug’s interaction with endogenous chemicals.

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Book ID Asin: 0367398346
Book Title: Drug Synergism and Dose-Effect Data Analysis
Book Author: Ronald J. Tallarida
Book Format: unknownBook Price: unknown
Book Category: Books, New, Used & Rental Textbooks, Medicine & Health Sciences and unknown
Book Rating: 2 ratings

Drug Synergism and Dose-Effect Data Analysis by Ronald J. Tallarida Book Review

Name: John L. Plummer
Rating: 5.0 out of 5 stars
Title: The definitive work
Date: Reviewed in the United States on September 21, 2000
Review: The statistical analysis of drug combination data in the literature is of a generally poor quality. This is not through lack of guidance in the literature, but rather because the relevant papers are scattered throughout the statistical and pharmacological literature, making it difficult for researchers to get a good overview of available methodology. What is needed is a single work where the required information is brought together. This book is it! The book covers most of the statistical methods required for drug combination studies, from designing the study to optimise power, fitting dose-response curves, to analysing the data. Many examples are given, which the reader can work through to confirm their understanding. The presentation is very clear, so even those with a limited knowledge of statistics should be able to follow it. The book does not aim to cover all of the available methods for analysing drug combination data, but the methods it does contain will be adequate in most cases. To balance my review I should point out the weak aspects of the book. It is not easy to find any. But maybe some of the material could have been omitted — for example formulas for calculating a linear regression and the variances of the estimates, which most researchers would just want to get from a computer output. Also, there are over 30 pages of tables, such as logarithms, probits, t-tables etc, which most researchers would have access to from other books, and which are rarely required as software normally does all the work. Besides, there is some strange formatting in Table A-2 (natural logarithms). For example, ln(0.1) is given as “7.6974–10”; why not just -2.3026? These criticisms are trivial in relation to the positive aspects. Any researcher studying drug combinations for synergistic or antagonistic effects will need this book. I like it.

Name: mark sexton
Rating: 5.0 out of 5 stars
Title: really good
Date: Reviewed in the United States on October 2, 2003
Review: A very well written walk through of basic knowledge into dose-response data and synergistic relationships. I found it very helpful.