Ethylone, what it is and how to use it

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6 min readMay 19, 2022

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Ethylone, also known as M2, MDEC or bk-MDEA is a stimulant and entactogenic research chemicals that is an analog of MDMA (methylonedioxymethamphetamine) and falls under the general category of phenetylamines.

Ethylone Crystal 99% Pure is very close chemically to its sister compound, methylone. It is slightly less potent than methylone by weight but will produce a similar experience.

Both methylone and ethylone are analogs of MDMA, differing by the beta-ketone group, and by the ethyl chain instead of methyl, in the case of ethylone. It is still legal in many countries and is one of the research chemicals that produce an effect very close to an MDMA experience.

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What is ethylone?

Ethylone is a synthetic cathinone which is a category of drugs related to the naturally occurring khat plant.1 Ethylone is also an empathogen. Empathogens increase an individual’s feeling of empathy and benevolence and increase feelings of being socially accepted by and connected to others.It’s effects are similar to other stimulant and empathogenic drugs such as MDMA, cocaine and amphetamines.2

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The chemical structure of synthetic cathinones continue to change, this is thought to be an attempt to avoid existing legal regulations.1 Ethylone began to appear in 2011 and is a newer form of another synthetic cathinone called methylone1 which first emerged in the early 2000s.3

What does ethylone look like? Ethylone can be a clear crystal or a white powder.4

Other names

Bath Salts, plant food, research chemicals, bk-MDEA, MDEC, and 3,4-methylenedioxy-N-ethylcathinone.

How is ethylone used?

Research on how ethylone is used is limited, however it is reported that synthetic cathinones are most commonly snorted or swallowed.5 Injecting, smoking, inhaling, as well as administering the drugs anally have also been reported.5

Effects of ethylone

There is no safe level of drug use. Use of any drug always carries some risk. It’s important to be careful when taking any type of drug.

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Ethylone can affect everyone differently, based on:

the amount taken

a person’s size, weight and health

whether the person is used to taking it

whether other drugs are taken around the same time

the strength of the drug (which can vary from batch to batch)

environment (where you take the drug).

Depending on the amount taken, the following effects may be experienced and may last up to four hours:

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  • euphoria
  • increased energy
  • heightened senses (sight, hearing and touch)
  • feelings of empathy and openness
  • increased sociability
  • decreased inhibition
  • sexual arousal
  • increased blood pressure
  • pupil dilation
  • reduced appetite

teeth or jaw clenching.5

Higher doses may result in the following adverse effects:

  • headache
  • agitation
  • insomnia
  • anxiety and paranoia
  • hallucinations
  • aggressive or violent behaviour
  • fast or irregular heartbeat
  • sweating and hot flushes
  • nausea and vomiting
  • cold extremities
  • dehydration
  • hyperthermia (high body temperature)
  • haemorrhage
  • psychosis
  • seizures
  • death.

Impact of mood and environment

Drugs that affect a person’s mental state (psychoactive drugs) can also have varied effects depending on a person’s mood (often called the ‘set’) or the environment they are in (the ‘setting’):

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Set: a person’s state of mind, previous encounters with empathogens, and expectations of what’s going to happen. For example, feelings of stress or anxiety before using ethylone may result in an unpleasant experience.8

Setting: the environment in which someone consumes an empathogen — whether it’s known and familiar, who they’re with, if they’re indoors or outdoors, the type of music and light. For example, using ethylone in a calm, quiet and relaxed environment can lead to, or contribute to, a pleasant experience but being in a noisy, crowded place may result in a negative experience.8

Being in a good state of mind, with trusted friends and a safe environment before taking ethylone reduces the risk of having a negative experience.

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Using ethylone with other drugs

The effects of combining synthetic cathinones (such as ethylone) with other drugs — including over-the-counter or prescribed medications — can be unpredictable and dangerous. The following combinations could have the following effects:

Synthetic cathinones + ice, speed or ecstasy: increase the risk of cardiovascular (heart) problems and substance-induced psychosis.5

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Synthetic cathinones + alcohol + cannabis: nausea and vomiting.

Health and safety

If possible, find out what a common dose is of ethylone is. As ethylone is a relatively new synthetic cathinone the harm reduction advice is partly based on what is known of related drugs like amphetamines and MDMA, as not enough research has been done on ethylone specifically.

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Use of ethylone is likely to be more dangerous when:

taken in combination with alcohol or other drugs, particularly stimulants such as crystal methamphetamine (‘ice’) or ecstasy

driving or operating heavy machinery

judgment or motor coordination is required

alone (in case medical assistance is required)

the person has a mental health condition

the person has an existing heart problem.

In Australia, poisons information centres and clinical toxicology units are often contacted for advice on poisonings from synthetic cathinones. Features of these poisonings include agitation, tachycardia (increased heart rate), hypertension and in severe cases delirium, aggressive behaviour, hallucinations, hyperthermia, cardiac dysrhythmia (irregular heartbeat) and seizures.8

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Injecting synthetic cathinones can cause soft tissue and vascular damage.

Sharing needles may also transmit:

  • Tetanus
  • Hepatitis B
  • Hepatitis C
  • HIV/AIDS.

Dependence and tolerance

Currently there isn’t available information on people seeking treatment for ethylone dependence.1 However, the limited information available on people who use synthetic cathinones shows that frequent use and large doses can lead to a strong compulsion to re-dose, as well as dependence, tolerance and withdrawal

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Synthetic cathinones made their appearance in the “drogosphere” in the early 2000s and today constitute one of the most widely used families of narcotics in Europe and North America. Juggling with the legality of their chemical structures, chemists and Reserach Chemicals websites have flooded the market with these diverse and varied substances with as yet unknown risks. The 2013 UN Report on Narcotics reports the explosion in the consumption of these synthetic drugs; in the USA, “bath salts” are the most widely used drugs among 15–24 year olds after cannabis.

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Mephedrone was first synthesized in 1929 by Saem de Burnaga Sanchez under the name “toluyl-alpha-monomethylaminoethyl ketone” whose work was published in the Bulletin de la Société Chimique de France. It was in 2003 that this substance was “revisited” by an “underground” chemist using the pseudonym “Kinetic” who published the first description of the effects of mephedrone on the Hive website. He will describe among other things “this incredible feeling of well-being that I could not find in any drug except my beloved ecstasy (MDMA)”.

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It is then in Israel that a new page in the history of synthetic cathinones will be written. Indeed, as of 2004, a derivative of cathinones is sold legally in the country under the name of hagigat . Declared illegal after two years, this derivative saw its molecular structure modified, then was again marketed by the Israeli company Neorganics under the name of Neodoves Pills. In July 2008, the Israeli government made all derivatives of cathinone illegal, but these stimulants were nevertheless to know their hours of glory, this time in Europe and the United States.

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Between 2007 and 2010, mephedrone was sold legally on RC websites, most often under the name “bath salts” or “fertilizer (plant food) “, until it was banned in the United Kingdom. United, a country at the forefront of Designer Drugs and where mephedrone was allegedly implicated in the deaths of several teenagers. From there, dozens of other cathinone derivatives were synthesized and marketed, some more successfully than others like methylone, butylone and MDPV.

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