Key Facts about Teicoplanin for Injection (Lyophilized)

Introduction

Teicoplanin for Injection (Lyophilized) is a glycopeptide antibiotic used primarily for the treatment of serious gram-positive bacterial infections. It exhibits bactericidal activity against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and other multidrug-resistant organisms. Teicoplanin is administered intravenously and is particularly valuable in situations where resistance to other antibiotics is a concern or when oral therapy is not feasible.

Composition

Each vial of Teicoplanin for Injection (Lyophilized) contains:

• Teicoplanin (as Teicoplanin Sodium): [Specify dosage strength]

Mechanism of Action

Teicoplanin acts by inhibiting bacterial cell wall synthesis. It binds to the D-alanyl-D-alanine terminus of cell wall precursors, thereby preventing peptidoglycan polymerization and disrupting bacterial cell wall integrity. This mechanism results in bacterial cell death.

Indications

Teicoplanin for Injection (Lyophilized) is indicated for the treatment of:

• Serious infections caused by gram-positive bacteria, including MRSA
• Infections in patients allergic to penicillin or when beta-lactam antibiotics are contraindicated

Dosage and Administration

• Adults: The usual dosage range is [Specify dosage regimen], administered intravenously over [Specify duration].
• Pediatric Patients: Dosage adjustments may be necessary based on age, weight, and renal function.
• Reconstitution and dilution should be performed according to manufacturer instructions to ensure proper administration.

Storage

• Store Teicoplanin for Injection (Lyophilized) at controlled room temperature (15–25°C).
• Protect from light and moisture.
• Keep out of reach of children.

Conclusion

Teicoplanin for Injection (Lyophilized) is an essential tool in the management of serious gram-positive bacterial infections, offering broad-spectrum activity and efficacy against resistant strains. Proper dosing, monitoring, and adherence to reconstitution guidelines are critical for maximizing therapeutic outcomes and minimizing adverse effects.

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