Jason Chin
May 19 · 1 min read

Even for small variants, there are many cases when there are “simple context” + “multiple variants” clustering together, any sequence aligner could have hard time to get consistent alignment outputs. In such case, the variants will be “complicate”. Even for more accurate reads, this can be still a problem. This paper has a summary of a couple of good examples: https://www.biorxiv.org/content/biorxiv/early/2018/05/24/270157.full.pdf

    Jason Chin

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    Common thing in the following subjects: physics, computation, bioinformatics, systems bio., software, engineering? -- A curious mind. The opinions are my own.