A summer conference may forever change the way scientists look at human aging. In late August 2014, some of the nation’s leading medical professionals will meet in Santa Clara, CA, to discuss various strategies for preventing age-related illnesses and to explore new ways to repair the damage these diseases cause to the body.

Rejuvenation Biotechnology Conference: Emerging Regenerative Medicine Solutions

SENS Research Foundation will hold the Rejuvenation Biotechnology Conference: Emerging Regenerative Medicine Solutions for the Diseases of Aging in Santa Clara, CA. …

Mitochondria are the “power plants” of your body’s cells. Mitochondria convert the nutrition inside your food into ATP, a type of energy that powers the biochemical reactions occurring in each of your cells. In a way, an individual mitochondrion is like a municipal power plant that serves a small city. Mitochondria turn resources into power the cell uses to function.

Cells are a bit like cities too, in that cells come equipped with DNA that tells various parts of the cell how to act – a bit similar to city planning concerned with the layout and design of the land…

Human body cells do not lead existential lives…

…Each cell in the human body has a predetermined fate. One cell might be destined to become skin while another cell is fated to be part of the liver.

But cells can sometimes be damaged in a way that causes them to diverge from the fate into which they were born. Cancer, for example, is a process in which mutations in the nuclear DNA and other changes cause cells to adopt a more primitive lifestyle and begin the uncontrolled growth that results in the formation of a tumor.

To guard against such risks, human cells do have built-in programming that…

Each day, body cells withstand a constant onslaught of destructive forces that can damage cells.

Each day, body cells withstand a constant onslaught of destructive forces that can damage cells. The body will attempt to either repair or destroy damaged cells using a type of cellular suicide known as apoptosis. Sometimes the body cannot destroy damaged cells completely so it forces these cells into a state somewhere between living and dead called “senescence,” where they stop growing in order to avert the possibility of the damaged cells becoming cancerous.

In many tissues, the body tries to replace lost cells quickly with specialized, tissue-specific stem cells. Exercise can stimulate the division of specialized stem cells in…

Sun, pollution and other external factors can hasten the signs of aging, but much of the aging process occurs deep within the human body.

SENS Foundation continues to break new ground in the fight against senescence, this time by addressing the aging process occurring in the tissues outside the cells that support them and guide their activities that are collectively known as the extracellular matrix.

The Extracellular Matrix

The extracellular matrix acts as a sort of scaffolding that provides support and cushioning to the surrounding cells. The extracellular matrix, or ECM, is an interlinking mesh of fibrous proteins and a few other substances that make the matrix both strong and elastic. The sturdy proteins that make up the matrix protect delicate organs and tissues from trauma and…

Waste disposal is a serious issue for humankind but also for cells inside the human body.

Cells create waste products and, left unaddressed, these byproducts disable body cells to cause serious illnesses. Scientists at SENS Research Foundation Research Center are currently developing ways to remove these waste products, known as lysosomal aggregates, from cells, in order to restore the cells to health and thereby treat these illnesses or prevent their onset. To understand the nature of the scientists’ work, it helpful to create a working analogy that makes understanding lysosomal aggregates easier.

Lysosomal Aggregates: Heaps of Unburnable Cellular Trash

Lysosomal aggregates are like non-biodegradable plastic bags and other garbage rising over the tops of landfills to pollute nearby land. Left unaddressed, unhealthy substances…

With funding from SENS Research Foundation, Albert Einstein College of Medicine (AECOM) Team members Dr. Vijg and Dr. Gravina have developed novel ways of identifying changes in the “scaffolding” that structures and controls the expression of the genetic code. These innovative approaches also help scientists determine if these changes in DNA are a response to environmental exposure or the result of damage to the scaffolding, leading to accumulating errors in the regulation of the DNA code. These methods may someday change the way doctors diagnose illnesses, such as cancer, and slow or reverse some of the debilitating effects of aging.

Changes in DNA Code

Little protein clumps called amyloids

Scientists at the SENS Research Foundation have been working on obliterating unhealthy extracellular aggregates, which is junk that accumulates between cells to cause dysfunction and early death. Also referred to as “amyloids,” these toxic little protein clumps can cause big problems.

The human body maintains the structure of the proteins and other structures of which it is composed in a delicate balance. Complex physiological functions ensure that its tissues retain their composition — proteins that are intended to remain in a form that keeps them soluble in body fluids, for example, while the proteins in bones stay stiff and solid.

Jason Hope

Philanthropy | Technology | Entrepreneur | http://jasonhope.com/philanthropy/

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