Open Knowledge and Advanced Systems Biology Day 1

Yesterday started with a course on, “building awareness of existing Open Knowledge tools and ways to leverage them, via self-organized lifelong learning, in order to build competencies for the 21st century society and its digital economy.” I created a personal skills map and compared it to current employment opportunities to effectively address gaps in my skills set. Then we went over how to continuously build a learning portfolio with proofs. Since each of our stories is so different there is no standard except that the proofs need to be collected and organized in a relatively cohesive and comprehensible way. The aim here is to be able to create a relevant portfolio to show a working process that results in skills. This portfolio should act as a clear indication of where we have come to propel us in the direction we want to go in our future.

Notes: Some start-ups work together for 6 months to pitch to investors for 4 minutes.

Beacons- a set of activities that a group of individuals agrees to practice over time as a means of self-repairing functional problems

examples:

benchmarking — what is the current state of the art or market at this time?

lectures — need to be made FUN

connections — talking to experts and peers regularly

activity — going to community events

experience— experiencing different types of this feild

research— researching topics

etc.

Degreed is the platform you can use to exhibit your degrees and skills across a broad variety of topics

Behance is a designers platform to exhibit skills and accomplishments

Homework in this class was to define beacons as a group, decide how you will track your progress, generate a learning experience summary of 2 weeks of learning with proofs (there was an example of a mind map which helps to visualize easy outcomes for proofs).

Advanced Systems Biology — Day 1

Basic cell biology is necessary to understand this class thus far.

1-Principles of Physiology

2-Principles of Endocrinology

3-Principles of Neuroscience

How are individual organisms integrated into a greater system?

There is analogous component structures working inside the cell to make the whole system function, as inside the body, as inside the social system.

Good now you’re ready to read the paper we had to read before class.

http://www.moodle-cri.org/pluginfile.php/20966/mod_resource/content/1/Michael%20et%20al.%2C%202009%20%28Review%29.pdf

Also fun and interesting apoptosis and cell necrosis. What are the differences? Which one is not common in plants?

November 23, Along with Alexis and Godlive, we will present a research paper on the neurobiology of emotions.

Next week : Hormonal Communication! YAY!

Critical analysis of this research paper chosen by classmates for Fridays discussion section: 2017.09.29 Z.Gere & P.Sinha: The evening complex coordinates environmental and endogenous signals in Arabidopsis

by Jessica Talley Sagot — Wednesday, 27 September 2017, 10:26 AM

+ The paper clearly aims to elucidate the coordination mechanisms between environmental signals and endogenous pathways in Arabidopsis during circadian oscillations. I could understand they were looking at patterns of binding sites and gene targets (Shown in Table 1). At least this part was clear.

+ RNA-sequencing, ChIP sequencing and Statistical tests used provide a nice foundation for multiple hypothesis testing.

+ I can appreciate that they chose a temperature responsive phenotypic parameter with elongation. It clearly exhibits the additive effects of phyB and elf3.

- The graphs are very difficult to comprehend. I cannot assess statistical significance just by looking at these.

- A non-specialist in the field of molecular biology will not readily understand this paper.

- It is unclear if they were able to effectively identify the functional targets or rather indirect targets of the EC.

The amount of acronyms and vocabulary is still beyond my scope of understanding. It would take me a considerable amount of time to define component significance. How is a paper like this effectively tackled by a non-expert in the field of molecular biology?

One clap, two clap, three clap, forty?

By clapping more or less, you can signal to us which stories really stand out.