2018 YC Start-up School Week 1

As co-founder of Lizora Health (AI Aided Precision Medicine),I started YC’s 2018 10-week Start-up School. Our first product is skin diseases diagnosis and treatment platform.Lizora Health is also member of NVIDIA’s AI & Machine Learning Incubator.

As everyone already knew, this year’s start-up school started with the mis-shape of emails. You are out first, and then you are in. We are the lucky one: we are in.

For our start-up, we are in the process of building our machine learning computer vision model, so joining the start-up school is more for the admiration of YC culture.

I am assigned to group 21, most of members in the group are health or biotech start-up. The mentor is Austin who was 2016 YC member and has experience with health and biotech.

Structure of start-up school:

  1. Classes: Each week, YC will pick a start-up topic and have classes in its Mountain View Class.

You have the choice to go to the weekly in-person classes in Mountain View or watch taped videos at your home.

2. Office-Hours: Each week, your group mentor will host 1 group office hour.

Basically, a video chat with other group members and your group mentor. Please noted that, YC specifically address the confidentiality issue, all conversation is off-the-record.

3. Weekly Update: Each week, you will set up metrics (growth rate, revenue, users…) and set up weekly targets and report them in the weekly report.

You need to file 9 out of 10 weekly report in order to pass the classes. If you are not sure about which metric to use, you can discuss it with your group mentor.

Week 1 Classes:

How to Succeed with a Startup

By Sam Altman


  1. Start-up cycle might be 10 years rather than just 2–3 years. You need to prepare your personal life and professional life to fit it.
  2. The next biggest cycle of tech: vertical integration of machine learning in every industry.
  3. Hire less people.

A Conversation with Paul Graham


  1. There is no way to tell it’s a good idea or not. Luck plays an important role.

2. Tell founders things they ignore.

3. Start-ups are counterintuitive meaning

4. Doing things manually for your customers

5. What makes start-ups fail? Poor execution of founders.

7. Determination is more important than being smart.