A Leslie Orgel professor at the University of Colorado, John Rinn teaches and mentors PhD students as well as studies human genome regulation. As part of this work, John Rinn co-authored the article “Interchromosomal interactions: A genomic love story of kissing chromosomes” with Philipp G. Maass and A. Rasim Barutcu.
Published in the Journal of Cell Biology, “Interchromosomal interactions: A genomic love story of kissing chromosomes” shares the results of a review of recent studies on cross-chromosomal communication. Aimed at identifying why and where chromosomal communication is pertinent to healthy physiological gene-expression programs, it features insight into how long three-dimensional gene positioning and noncoding RNAs influence genome organization. Additionally, it discusses how high-throughput (Hi-C and SPRITE) and low-throughput (live-cell imaging) techniques take effect in order to better understand the elemental properties of interchromosomal interactions.
The review was inspired in part by recent discoveries on how chromosomes communicate. Most current research focuses on how chromosomes speak to themselves, but chromosomes are also able to make long-distance contacts through interchromosomal interactions.
