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Smoking crack allows it to reach the brain more quickly and thus brings an intense and immediate-but very short-lived-high that lasts about fifteen minutes. And because addiction can develop even more rapidly if the substance is smoked rather than snorted (taken in through the nose), an abuser can become addicted after his or her first time trying crack. Cocaine Hydrochloride. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. Its effect on dopamine levels causes CNS stimulation and euphoria, and ultimately dependence. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.
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