Volume to Egress Ratio
A thought, and not necessarily a good one, is that we can, to some degree, compare how much “trades” in a 24 hour window on an exchange with how much the exchange distributes to users via withdrawals.
This isn’t necessarily super stable. Different platforms have different usage patterns. I’ve looked at only ETH withdrawals only from the exchange addresses of which I know. Would love some help in adding to the list of known ETH wallet addresses that platforms are using to service withdrawals.

I grabbed all the transactions over the past few days, and compared yesterday’s volume data (via CMC) to the median ETH sent out of the known wallets over the past 3 days.
A few outliers:
Gemini: Very low. ~1000 to 1. Perhaps a function of their user base. (And their fees)
OKEx, HitBTC, CoinEx: 58,000 : 1 ; 83,000 : 1; 167,000 : 1. That’s about 5, 8, and 17 times respectively Binance’s ratio of trading to withdrawals.

I’ll put together the data and code shortly for those interested.
The address set I’m working off of:
addresses = {
'BINANCE': ['0x3f5ce5fbfe3e9af3971dd833d26ba9b5c936f0be', '0xd551234ae421e3bcba99a0da6d736074f22192ff',
'0x564286362092d8e7936f0549571a803b203aaced', '0x0681d8db095565fe8a346fa0277bffde9c0edbbf',
'0xfe9e8709d3215310075d67e3ed32a380ccf451c8'],
'COINEX': ['0xb9ee1e551f538a464e8f8c41e9904498505b49b0'],
'BITFINEX': ['0x1151314c646ce4e0efd76d1af4760ae66a9fe30f', '0x7727e5113d1d161373623e5f49fd568b4f543a9e',
'0x4fdd5eb2fb260149a3903859043e962ab89d8ed4', '0x876eabf441b2ee5b5b0554fd502a8e0600950cfa',
'0x742d35cc6634c0532925a3b844bc454e4438f44e'],
'BITTREX': ['0xfbb1b73c4f0bda4f67dca266ce6ef42f520fbb98', '0xe94b04a0fed112f3664e45adb2b8915693dd5ff3'],
'COBINHOOD': ['0x8958618332df62af93053cb9c535e26462c959b0'],
'CHANGELLY': ['0x96fc4553a00c117c5b0bed950dd625d1c16dc894'],
'CRYPTOPIA': ['0x5baeac0a0417a05733884852aa068b706967e790'],
'GATEIO': ['0x0d0707963952f2fba59dd06f2b425ace40b492fe', '0x7793cd85c11a924478d358d49b05b37e91b5810f',
'0x1c4b70a3968436b9a0a9cf5205c787eb81bb558c'],
'GEMINI': ['0xd24400ae8bfebb18ca49be86258a3c749cf46853', '0x6fc82a5fe25a5cdb58bc74600a40a69c065263f8'],
'HITBTC': ['0x9c67e141c0472115aa1b98bd0088418be68fd249', '0x59a5208b32e627891c389ebafc644145224006e8'],
'HUOBI': ['0xab5c66752a9e8167967685f1450532fb96d5d24f', '0x6748f50f686bfbca6fe8ad62b22228b87f31ff2b',
'0xfdb16996831753d5331ff813c29a93c76834a0ad', '0xeee28d484628d41a82d01e21d12e2e78d69920da',
'0x5c985e89dde482efe97ea9f1950ad149eb73829b', '0xdc76cd25977e0a5ae17155770273ad58648900d3',
'0xadb2b42f6bd96f5c65920b9ac88619dce4166f94', '0xa8660c8ffd6d578f657b72c0c811284aef0b735e',
'0x1062a747393198f70f71ec65a582423dba7e5ab3', '0xe93381fb4c4f14bda253907b18fad305d799241a',
'0xfa4b5be3f2f84f56703c42eb22142744e95a2c58', '0x46705dfff24256421a05d056c29e81bdc09723b8',
'0x99fe5d6383289cdd56e54fc0baf7f67c957a8888'],
'KRAKEN': ['0x2910543af39aba0cd09dbb2d50200b3e800a63d2', '0x0a869d79a7052c7f1b55a8ebabbea3420f0d1e13',
'0xe853c56864a2ebe4576a807d26fdc4a0ada51919', '0x267be1c1d684f78cb4f6a176c4911b741e4ffdc0',
'0xfa52274dd61e1643d2205169732f29114bc240b3'],
'KUCOIN': ['0x2b5634c42055806a59e9107ed44d43c426e58258'],
'OKEX': ['0x6cc5f688a315f3dc28a7781717a9a798a59fda7b'],
'POLONIEX': ['0x32be343b94f860124dc4fee278fdcbd38c102d88', '0xab11204cfeaccffa63c2d23aef2ea9accdb0a0d5',
'0x209c4784ab1e8183cf58ca33cb740efbf3fc18ef', '0xb794f5ea0ba39494ce839613fffba74279579268'],
'SHAPESHIFT': ['0x70faa28a6b8d6829a4b1e649d26ec9a2a39ba413'],
}