The ad producers need to be less invasive and less annoying. The focus needs to shift to courtesy towards those who aren't interested. No more ads with audio that randomly start playing on hidden tabs. No more ads that manipulate or scroll the content around it, eg vertical slide-ins.

This is a shift from goal of maximizing clicks and doing what the math says makes the most clicks. The extra bonus you get from those tactics is a huge factor in the motivation to seek an ad blocker.

Form a committee to set rules and make membership something to be proud of to avoid the bad actors driving all ad producers towards toward bad behavior.

Either way, until people find more clever but unobtrusive styles of ads, there’s going to be a decrease of money flowing through advertising.

The only question is if it will be the whole $50,000,000,000, or just a small fraction? And the answer is dependent on the behavior of the advertisers.