I already use a transpiled language. It’s called ES2015 (or ES6). And you are right, it makes writing SPAs much less complicated. I expect my investment in Javascript and its more advanced dialects thereof to be preserved 100% when/if Web-Assembly comes out. And in that period of time I will be able to recruit from the vast array of developers conversant in that language, rather than looking for a niche Clojure expert.